Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/95726
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dc.contributor.authorSürth, Valerie-
dc.contributor.authorCarvalho, Isabel Lopes de-
dc.contributor.authorNúncio, Maria Sofia-
dc.contributor.authorNorte, Ana Cláudia-
dc.contributor.authorKraiczy, Peter-
dc.date.accessioned2021-09-14T15:32:45Z-
dc.date.available2021-09-14T15:32:45Z-
dc.date.issued2021-09-06-
dc.identifier.issn1756-3305pt
dc.identifier.urihttp://hdl.handle.net/10316/95726-
dc.description.abstractComplement has been considered as an important factor impacting the host-pathogen association of spirochetes belonging to the Borrelia burgdorferi sensu lato complex, and may play a role in the spirochete's ecology. Birds are known to be important hosts for ticks and in the maintenance of borreliae. Recent field surveys and laboratory transmission studies indicated that certain avian species act as reservoir hosts for different Borrelia species. Nevertheless, our current understanding of the molecular mechanisms determining host tropism of Borrelia is still in its fledgling stage. Concerning the role of complement in avian-host tropism, only a few bird species and Borrelia species have been analysed so far. Here, we performed in vitro serum bactericidal assays with serum samples collected from four bird species including the European robin Erithacus rubecula, the great tit Parus major, the Eurasian blackbird Turdus merula, and the racing pigeon Columba livia, as well as four Borrelia species (B. afzelii, B. garinii, B. valaisiana, and B. burgdorferi sensu stricto). From July to September 2019, juvenile wild birds were caught using mist nets in Portugal. Racing pigeons were sampled in a loft in October 2019. Independent of the bird species analysed, all Borrelia species displayed an intermediate serum-resistant or serum-resistant phenotype except for B. afzelii challenged with serum from blackbirds. This genospecies was efficiently killed by avian complement, suggesting that blackbirds served as dead-end hosts for B. afzelii. In summary, these findings suggest that complement contributes in the avian-spirochete-tick infection cycle and in Borrelia-host tropism.pt
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL. This study received financial support from Fundação para a Ciência e a Tecnologia by the strategic program of MARE (MARE—UID/MAR/04292/2020) and the transitory norm contract DL57/2016/CP1370/CT89 to ACN, and the Portuguese National Institute of Health (INSA).pt
dc.language.isoengpt
dc.publisherBMCpt
dc.relationUID/MAR/04292/2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectAvianpt
dc.subjectBirdspt
dc.subjectBorreliapt
dc.subjectComplementpt
dc.subjectHost tropismpt
dc.subjectImmune evasionpt
dc.subjectInnate immunity;pt
dc.subjectIxodespt
dc.subjectSpirochetespt
dc.subjectTickpt
dc.titleBactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliaept
dc.typearticle-
degois.publication.firstPage451pt
degois.publication.issue1pt
degois.publication.titleParasites & Vectorspt
dc.peerreviewedyespt
dc.identifier.doi10.1186/s13071-021-04959-0pt
degois.publication.volume14pt
dc.date.embargo2021-09-06*
uc.date.periodoEmbargo0pt
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.orcid0000-0001-7833-4463-
Appears in Collections:I&D MARE - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons