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Title: Sequential catalytic carbonylation reactions for sustainable synthesis of biologically relevant entities
Authors: Damas, Liliana Reis 
Rodrigues, Fábio M.S. 
Gonzalez, Andreia C.S.
Carrilho, Rui Miguel Barroso 
Piñeiro Gomez, Marta 
Pereira, Maria Miguéns 
Keywords: Sequential reactions; Aminocarbonylation; Hydroformylation; Microwave synthesis; N-heterocyclesChalcones
Issue Date: 2020
Publisher: Elsevier
Project: info:eu-repo/grantAgreement/FCT/00313/2019/PT 
PTDC/QUI-OUT/27996/2017 (DUALPI) 
Volume: 923
Abstract: The sustainable synthesis of highly functionalised formylcarboxamide compounds with biological relevance is reported through a sequential aminocarbonylation/hydroformylation approach. The optimisation of palladium-catalysed aminocarbonylation of iodoaromatic substrates, using allylamine as nucleophile was first performed, with molybdenum hexacarbonyl as alternative CO source versus gaseous carbon monoxide. The combination of microwave irradiation with molybdenum hexacarbonyl allowed to selectively prepare a set of N-heterocyclic-based allylcarboxamides. Subsequent rhodium-catalysed hydroformylation of the allylcarboxamide intermediates led to the preparation of new pyridine, pyrazoline and chalcone derivatives containing both carboxamide and formyl moieties.
ISSN: 0022328X
DOI: 10.1016/j.jorganchem.2020.121417
Rights: embargoedAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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