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Title: | Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine | Authors: | Ferreira, Raquel Napoli, Joseph Enver, Tariq Bernardino, Liliana Ferreira, Lino |
Issue Date: | 26-Aug-2020 | Publisher: | Nature | Project: | 2IQBIONEURO (reference: 0624_2IQBIONEURO_6_E) POCI-01-0145- 619 FEDER-029414 (acronym: LIghtBRARY) NEUROATLANTIC (reference: EAPA_791/2018) SFRH/BPD/94228/2013 IF/00178/2015 CENTRO-01-0145-FEDER-000013/ICON - Interdisciplinary Challenges On Neurodegeneration EXPL/BIM-MED/0822/2013 (LB) info:eu-repo/grantAgreement/EC/H2020/669088/EU/Enhancing Research in Ageing at the University of Coimbra SFRH/BPD/102103/2014 POCI-01-0145-FEDER-016390 UID/Multi/00709/2013) |
Serial title, monograph or event: | Nature Communications | Volume: | 11 | Abstract: | Retinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits make retinoids very attractive molecules for medical purposes. In light of some of the physicochemical limitations of retinoids, the development of drug delivery systems offers several advantages for clinical translation of retinoid-based therapies, including improved solubilization, prolonged circulation, reduced toxicity, sustained release, and improved efficacy. In this Review, we discuss advances in preclinical and clinical tests regarding retinoid formulations, specifically the ones based in natural retinoids, evaluated in the context of regenerative medicine, brain, cancer, skin, and immune diseases. Advantages and limitations of retinoid formulations, as well as prospects to push the field forward, will be presented. | URI: | https://hdl.handle.net/10316/92473 | DOI: | 10.1038/s41467-020-18042-2 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Ferreira et al., Nat Communications.pdf | 2.03 MB | Adobe PDF | View/Open |
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