Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/92473
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dc.contributor.authorFerreira, Raquel-
dc.contributor.authorNapoli, Joseph-
dc.contributor.authorEnver, Tariq-
dc.contributor.authorBernardino, Liliana-
dc.contributor.authorFerreira, Lino-
dc.date.accessioned2021-01-14T12:06:01Z-
dc.date.available2021-01-14T12:06:01Z-
dc.date.issued2020-08-26-
dc.identifier.urihttp://hdl.handle.net/10316/92473-
dc.description.abstractRetinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits make retinoids very attractive molecules for medical purposes. In light of some of the physicochemical limitations of retinoids, the development of drug delivery systems offers several advantages for clinical translation of retinoid-based therapies, including improved solubilization, prolonged circulation, reduced toxicity, sustained release, and improved efficacy. In this Review, we discuss advances in preclinical and clinical tests regarding retinoid formulations, specifically the ones based in natural retinoids, evaluated in the context of regenerative medicine, brain, cancer, skin, and immune diseases. Advantages and limitations of retinoid formulations, as well as prospects to push the field forward, will be presented.pt
dc.description.sponsorshipCerebrovascular Disease Grant and L’Oréal-UNESCO Portugal for Women in Sciencept
dc.language.isoengpt
dc.publisherNaturept
dc.relationPOCI-01-0145-FEDER-016390 (acronym: CANCEL STEM)pt
dc.relation2IQBIONEURO (reference: 0624_2IQBIONEURO_6_E)pt
dc.relationUID/Multi/00709/2013pt
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/669088/EUpt
dc.relationPOCI-01-0145- 619 FEDER-029414 (acronym: LIghtBRARY)pt
dc.relationNEUROATLANTIC (reference: EAPA_791/2018)pt
dc.relationinfo:eu-repo/grantAgreement/RCUK/Innovate UK/102103/GB/Veterinary clinical data surveillancept
dc.relationSFRH/BPD/102103/2014 624 (UID/Multi/00709/2013), “Programa Operacional do Centro, Centro 2020” through the funding of 625 the ICON project (Interdisciplinary Challenges On Neurodegeneration; CENTRO-01-0145- 626 FEDER-000013), EXPL/BIM-MED/0822/2013 (LB), (SFRH/BPD/94228/2013, IF/00178/2015) 627 (RF),pt
dc.relationSFRH/BPD/94228/2013, IF/00178/2015pt
dc.relationinfo:eu-repo/grantAgreement/RCUK/Innovate UK/120146/GB/ICONpt
dc.relationCENTRO-01-0145- 626 FEDER-000013pt
dc.relationEXPL/BIM-MED/0822/2013pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.titleAdvances and challenges in retinoid delivery systems in regenerative and therapeutic medicinept
dc.typearticle-
degois.publication.titleNature Communicationspt
dc.peerreviewedyespt
dc.identifier.doi10.1038/s41467-020-18042-2pt
degois.publication.volume11pt
dc.date.embargo2020-08-26*
uc.date.periodoEmbargo0pt
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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