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Title: Innate Lymphoid Cells in Human Pregnancy
Authors: Mendes, João
Areia, Ana Luísa
Rodrigues-Santos, Paulo
Santos-Rosa, Manuel 
Mota-Pinto, Anabela 
Keywords: Células Linfoides Inatas; Resposta imunitária inata; Inflamação; Gravidez; Parto pré-termo; Inflammation; Innate Lymphoid Cells; Innate immune response; Pregnancy; Preterm birth
Issue Date: 30-Nov-2020
Serial title, monograph or event: Frontiers in Immunology
Volume: 11
Abstract: Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Functionally, these cells resemble the T helper population but lack the expression of recombinant genes, which is essential for the formation of T cell receptors. In this work, the authors address the distinction between peripheral and decidual NK cells, highlighting their diversity in ILC biology and its relevance to human pregnancy. ILCs are effector cells that are important in promoting immunity, inflammation, and tissue repair. Recent studies have directed their attention to ILC actions in pregnancy. Dysregulation or expansion of pro-inflammatory ILC populations as well as abnormal tolerogenic responses may directly interfere with pregnancy, ultimately resulting in pregnancy loss or adverse outcomes. In this review, we characterize these cells, considering recent findings and addressing knowledge gaps in perinatal medicine in the context of ILC biology. Moreover, we discuss the relevance of these cells not only to the process of immune tolerance, but also in disease.
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.551707
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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