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https://hdl.handle.net/10316/91066
Título: | Targeted siRNA Delivery Using Lipid Nanoparticles | Autor: | Jorge, Andreia Pais, Alberto Vitorino, Carla |
Palavras-chave: | RNA interference; Solid lipid-based nanoparticles; Targeting; siRNA delivery; Temperature-based methods; Solvent-based methods | Data: | 2020 | Editora: | Springer Nature | Projeto: | POCI-01-0145-FEDER- 016648 PEst- UID/NEU/04539/2013 POCI-01- 0145-FEDER-007440 CENTRO-01-0145-FEDER-030752 PEst- OE/QUI/UI0313/2014 POCI-01-0145-FEDER-007630 SFRH/BPD/104544/2014 |
Título da revista, periódico, livro ou evento: | Drug Delivery Systems | Volume: | 2059 | Resumo: | Efficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the clinics. Solid lipid-based nanoparticles (SLNs) and derivatives can potentially fit this purpose by enabling to overcome the extracellular and intracellular physiological barriers affecting the delivery. For that, rational formulations and rational process designs are needed. This chapter addresses a comprehensive description and critical appraisal of the main production methods of this particular type of lipid nanoparticles and the leading strategies to prompt a targeted delivery of siRNA. | URI: | https://hdl.handle.net/10316/91066 | ISBN: | 978-1-4939-9797-8 | DOI: | 10.1007/978-1-4939-9798-5_14 | Direitos: | embargoedAccess |
Aparece nas coleções: | I&D CQC - Livros e capítulos de livros |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Chapter_14.pdf | 293.95 kB | Adobe PDF | Ver/Abrir |
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