Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/91066
DC FieldValueLanguage
dc.contributor.authorJorge, Andreia-
dc.contributor.authorPais, Alberto-
dc.contributor.authorVitorino, Carla-
dc.date.accessioned2020-09-18T12:03:40Z-
dc.date.available2020-09-18T12:03:40Z-
dc.date.issued2020-
dc.identifier.isbn978-1-4939-9797-8pt
dc.identifier.urihttps://hdl.handle.net/10316/91066-
dc.description.abstractEfficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the clinics. Solid lipid-based nanoparticles (SLNs) and derivatives can potentially fit this purpose by enabling to overcome the extracellular and intracellular physiological barriers affecting the delivery. For that, rational formulations and rational process designs are needed. This chapter addresses a comprehensive description and critical appraisal of the main production methods of this particular type of lipid nanoparticles and the leading strategies to prompt a targeted delivery of siRNA.pt
dc.language.isoengpt
dc.publisherSpringer Naturept
dc.relationPOCI-01-0145-FEDER- 016648pt
dc.relationPEst- UID/NEU/04539/2013pt
dc.relationPOCI-01- 0145-FEDER-007440pt
dc.relationCENTRO-01-0145-FEDER-030752pt
dc.relationPEst- OE/QUI/UI0313/2014pt
dc.relationPOCI-01-0145-FEDER-007630pt
dc.relationSFRH/BPD/104544/2014pt
dc.rightsembargoedAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectRNA interferencept
dc.subjectSolid lipid-based nanoparticlespt
dc.subjectTargetingpt
dc.subjectsiRNA deliverypt
dc.subjectTemperature-based methodspt
dc.subjectSolvent-based methodspt
dc.titleTargeted siRNA Delivery Using Lipid Nanoparticlespt
dc.typebookpt
degois.publication.firstPage259pt
degois.publication.lastPage283pt
degois.publication.titleDrug Delivery Systemspt
dc.relation.publisherversionhttps://link.springer.com/protocol/10.1007%2F978-1-4939-9798-5_14pt
dc.peerreviewedyespt
dc.identifier.doi10.1007/978-1-4939-9798-5_14pt
degois.publication.volume2059pt
dc.date.embargo2022-11-16*
uc.date.periodoEmbargo1050pt
item.openairecristypehttp://purl.org/coar/resource_type/c_2f33-
item.openairetypebook-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-6725-6460-
crisitem.author.orcid0000-0003-3424-548X-
Appears in Collections:I&D CQC - Livros e capítulos de livros
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