Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/91066
Title: Targeted siRNA Delivery Using Lipid Nanoparticles
Authors: Jorge, Andreia
Pais, Alberto 
Vitorino, Carla 
Keywords: RNA interference; Solid lipid-based nanoparticles; Targeting; siRNA delivery; Temperature-based methods; Solvent-based methods
Issue Date: 2020
Publisher: Springer Nature
Project: POCI-01-0145-FEDER- 016648 
PEst- UID/NEU/04539/2013 
POCI-01- 0145-FEDER-007440 
CENTRO-01-0145-FEDER-030752 
PEst- OE/QUI/UI0313/2014 
POCI-01-0145-FEDER-007630 
SFRH/BPD/104544/2014 
Serial title, monograph or event: Drug Delivery Systems
Volume: 2059
Abstract: Efficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the clinics. Solid lipid-based nanoparticles (SLNs) and derivatives can potentially fit this purpose by enabling to overcome the extracellular and intracellular physiological barriers affecting the delivery. For that, rational formulations and rational process designs are needed. This chapter addresses a comprehensive description and critical appraisal of the main production methods of this particular type of lipid nanoparticles and the leading strategies to prompt a targeted delivery of siRNA.
URI: http://hdl.handle.net/10316/91066
ISBN: 978-1-4939-9797-8
DOI: 10.1007/978-1-4939-9798-5_14
Rights: embargoedAccess
Appears in Collections:I&D CQC - Livros e capítulos de livros

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