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https://hdl.handle.net/10316/90884
Title: | Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration | Authors: | Gonçalves, Joana Alves, Gilberto Carona, Andreia Bicker, Joana Vitorino, Carla Falcão, Amílcar Fortuna, Ana |
Keywords: | Zonisamide; Epilepsy; Intranasal; Mice; Nose-to-brain; Pharmacokinetics | Issue Date: | 25-Mar-2020 | Publisher: | Springer Nature | Project: | CENTRO-01-0145-FEDER-03075 POCI-01-0145- FEDER-030478 |
Serial title, monograph or event: | Pharmaceutical Research | Volume: | 37 | Issue: | 4 | Abstract: | Zonisamide clinical indications are expanding beyond the classic treatment of epileptic seizures to Parkinson's disease and other neurodegenerative diseases. However, the systemic safety profile of zonisamide may compromise its use as a first-line drug in any clinical condition. Since zonisamide is marketed as oral formulations, the present study aimed at exploring the potential of the intranasal route to centrally administer zonisamide, evaluating the systemic bioavailability of zonisamide and comparing its brain, lung and kidney pharmacokinetics after intranasal, oral and intravenous administrations. | URI: | https://hdl.handle.net/10316/90884 | ISSN: | 0724-8741 1573-904X |
DOI: | 10.1007/s11095-020-02786-z | Rights: | openAccess |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
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