Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/90884
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gonçalves, Joana | - |
dc.contributor.author | Alves, Gilberto | - |
dc.contributor.author | Carona, Andreia | - |
dc.contributor.author | Bicker, Joana | - |
dc.contributor.author | Vitorino, Carla | - |
dc.contributor.author | Falcão, Amílcar | - |
dc.contributor.author | Fortuna, Ana | - |
dc.date.accessioned | 2020-09-09T16:19:57Z | - |
dc.date.available | 2020-09-09T16:19:57Z | - |
dc.date.issued | 2020-03-25 | - |
dc.identifier.issn | 0724-8741 | pt |
dc.identifier.issn | 1573-904X | pt |
dc.identifier.uri | https://hdl.handle.net/10316/90884 | - |
dc.description.abstract | Zonisamide clinical indications are expanding beyond the classic treatment of epileptic seizures to Parkinson's disease and other neurodegenerative diseases. However, the systemic safety profile of zonisamide may compromise its use as a first-line drug in any clinical condition. Since zonisamide is marketed as oral formulations, the present study aimed at exploring the potential of the intranasal route to centrally administer zonisamide, evaluating the systemic bioavailability of zonisamide and comparing its brain, lung and kidney pharmacokinetics after intranasal, oral and intravenous administrations. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | CENTRO-01-0145-FEDER-03075 | pt |
dc.relation | POCI-01-0145- FEDER-030478 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Zonisamide | pt |
dc.subject | Epilepsy | pt |
dc.subject | Intranasal | pt |
dc.subject | Mice | pt |
dc.subject | Nose-to-brain | pt |
dc.subject | Pharmacokinetics | pt |
dc.title | Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration | pt |
dc.type | article | - |
degois.publication.firstPage | 74 | pt |
degois.publication.issue | 4 | pt |
degois.publication.title | Pharmaceutical Research | pt |
dc.relation.publisherversion | https://link.springer.com/content/pdf/10.1007/s11095-020-02786-z.pdf | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1007/s11095-020-02786-z | pt |
degois.publication.volume | 37 | pt |
dc.date.embargo | 2020-03-25 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Faculty of Pharmacy | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-6641-210X | - |
crisitem.author.orcid | 0000-0003-3424-548X | - |
crisitem.author.orcid | 0000-0002-3854-6549 | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Pharm_Res.pdf | 805.3 kB | Adobe PDF | View/Open |
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