Title: Heterodimeric adenosine receptors: a device to regulate neurotransmitter release
Authors: Ciruela, F. 
Ferré, S. 
Casadó, V. 
Cortés, A. 
Cunha, R. 
Lluis, C. 
Franco, R. 
Issue Date: 2006
Citation: Cellular and Molecular Life Sciences (CMLS). 63:21 (2006) 2427-2431
Abstract: Abstract. Since 1990 it has been known that dimers are the basic functional form of nearly all G-protein-coupled receptors (GPCRs) and that homo- and heterodimerization may play a key role in correct receptor maturation and trafficking to the plasma membrane. Nevertheless, homo- and heterodimerization of GPCR has become a matter of debate especially in the search for the precise physiological meaning of this phenomenon. This article focuses on how heterodimerization of adenosine A1 and A2A receptors, which are coupled to apparently opposite signalling pathways, allows adenosine to exert a fine-tuning modulation of striatal glutamatergic neurotransmission, providing a switch mechanism by which low and high concentrations of adenosine inhibit and stimulate, respectively, glutamate release.
URI: http://hdl.handle.net/10316/8506
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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