Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/8506
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ciruela, F. | - |
dc.contributor.author | Ferré, S. | - |
dc.contributor.author | Casadó, V. | - |
dc.contributor.author | Cortés, A. | - |
dc.contributor.author | Cunha, R. | - |
dc.contributor.author | Lluis, C. | - |
dc.contributor.author | Franco, R. | - |
dc.date.accessioned | 2009-02-17T10:50:44Z | - |
dc.date.available | 2009-02-17T10:50:44Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Cellular and Molecular Life Sciences (CMLS). 63:21 (2006) 2427-2431 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/8506 | - |
dc.description.abstract | Abstract. Since 1990 it has been known that dimers are the basic functional form of nearly all G-protein-coupled receptors (GPCRs) and that homo- and heterodimerization may play a key role in correct receptor maturation and trafficking to the plasma membrane. Nevertheless, homo- and heterodimerization of GPCR has become a matter of debate especially in the search for the precise physiological meaning of this phenomenon. This article focuses on how heterodimerization of adenosine A1 and A2A receptors, which are coupled to apparently opposite signalling pathways, allows adenosine to exert a fine-tuning modulation of striatal glutamatergic neurotransmission, providing a switch mechanism by which low and high concentrations of adenosine inhibit and stimulate, respectively, glutamate release. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Heterodimeric adenosine receptors: a device to regulate neurotransmitter release | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1007/s00018-006-6216-2 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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