Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/8500
Título: | Association and Expression Study of PRKCH Gene in a French Caucasian Population with Rheumatoid Arthritis | Autor: | Teixeira, Vitor Jacq, Laurent Moore, Jeoiakim Lasbleiz, Sandra Hilliquin, Pascal Oliveira, Catarina Resende Cornelis, François Petit-Teixeira, Elisabeth |
Data: | 2008 | Citação: | Journal of Clinical Immunology. 28:2 (2008) 115-121 | Resumo: | We study the association between three protein kinase C, eta gene polymorphisms (+8134C/T, rs912620, rs959728), and susceptibility to rheumatoid arthritis. One hundred French Caucasian rheumatoid arthritis trio families were genotyped. Relative quantification of protein kinase C, eta mRNA expression was performed from whole blood in 24 unrelated rheumatoid arthritis patients and in 16 healthy controls. Our results showed no significant association or linkage between the protein kinase C, eta polymorphisms, and rheumatoid arthritis. The protein kinase C, eta mRNA was expressed at lower level in rheumatoid arthritis unrelated patients than in healthy controls. This study shows that protein kinase C, eta gene is not a Rheumatoid Arthritis major susceptibility genetic factor in the French Caucasian population. Furthermore, the lower expression of this gene in rheumatoid arthritis patients comparing to healthy controls suggests that protein kinase C, eta could be associated with the patho-physiologic mechanism of rheumatoid arthritis. | URI: | https://hdl.handle.net/10316/8500 | DOI: | 10.1007/s10875-007-9143-6 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Mostrar registo em formato completo
Citações SCOPUSTM
6
Visto em 9/nov/2022
Citações WEB OF SCIENCETM
10
6
Visto em 2/mai/2023
Visualizações de página
385
Visto em 11/set/2024
Downloads
377
Visto em 11/set/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.