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Title: | A comparative study of reactivity and selectivity of chiral diamines and structurally analogous amino alcohol ligands in enantioselective alkylations with diethylzinc | Authors: | Serra, M. Elisa Silva Murtinho, Dina Gonsalves, A. M. d'A. Rocha |
Issue Date: | 2008 | Citation: | Applied Organometallic Chemistry. 22:9 (2008) 488-493 | Abstract: | A series of chiral delta-diamines and structurally analogous delta-amino alcohols derived from natural tartaric acid were synthesized and a comparative study of their activity and selectivity in the enantioselective alkylation of aromatic aldehydes was carried out. Our results show that in general the delta-diamines were found to be better chiral inducers than the corresponding delta-amino alcohols. The highest selectivity was observed when benzaldehyde was alkylated in the presence of the benzylic diamine, giving (R)-1-phenylpropanol with an ee of 42%. Copyright © 2008 John Wiley & Sons, Ltd. | URI: | https://hdl.handle.net/10316/8253 | DOI: | 10.1002/aoc.1428 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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