Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/8240
Título: | Simple measurement of gluconeogenesis by direct 2H NMR analysis of menthol glucuronide enrichment from 2H2O | Autor: | Ribeiro, Angela Caldeira, M. Madalena Carvalheiro, Manuela Bastos, Margarida Baptista, Carla Fagulha, Ana Barros, Luisa Barosa, Cristina Jones, John G. |
Data: | 2005 | Citação: | Magnetic Resonance in Medicine. 54:2 (2005) 429-434 | Resumo: | The contribution of gluconeogenesis to fasting glucose production was determined by a simple measurement of urinary menthol glucuronide (MG) 2H enrichment from 2H2O. Following ingestion of 2H2O (0.5% body water) during an overnight fast and a pharmacological dose (400 mg) of a commercial peppermint oil preparation the next morning, 364 mumol MG was quantitatively recovered from a 2-h urine collection by ether extraction and a 125 mumol portion was directly analyzed by 2H NMR. The glucuronide 2H-signals were fully resolved and their relative intensities matched those of the monoacetone glucose derivative. The pharmacokinetics and yields of urinary MG after ingestion of 400 mg peppermint oil as either gelatin or enteric-coated capsules 1 h before breakfast were quantified in five healthy subjects. Gelatin capsules yielded 197 ± 81 mumol of MG from the initial 2-h urine collection while enteric-coated capsules gave 238 ± 84 mumol MG from the 2- to 4-h urine collection. Magn Reson Med 54:429-434, 2005. © 2005 Wiley-Liss, Inc. | URI: | https://hdl.handle.net/10316/8240 | DOI: | 10.1002/mrm.20567 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais |
Mostrar registo em formato completo
Citações SCOPUSTM
17
Visto em 14/out/2024
Citações WEB OF SCIENCETM
5
16
Visto em 2/out/2024
Visualizações de página
274
Visto em 15/out/2024
Downloads
187
Visto em 15/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.