Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/8105
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Carvalho, Rui A. | - |
dc.contributor.author | Babcock, Evelyn E. | - |
dc.contributor.author | Jeffrey, F. Mark H. | - |
dc.contributor.author | Sherry, A. Dean | - |
dc.contributor.author | Malloy, Craig R. | - |
dc.date.accessioned | 2009-02-09T11:10:40Z | - |
dc.date.available | 2009-02-09T11:10:40Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Magnetic Resonance in Medicine. 42:1 (1999) 197-200 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/8105 | - |
dc.description.abstract | Most 13C nuclear magnetic resonance (NMR) isotopomer analyses relate a metabolic index of interest to populations of 13C isotopomers as reported by one-bond 13C-13C spin-spin couplings. Metabolic conditions that produce highly enriched citric acid cycle intermediates often lead to 13C NMR spectra of metabolites such as glutamate that show extra multiplets due to long-range couplings. It can be demonstrated from 13C NMR spectra of hearts perfused with mixtures of acetate plus propionate that multiplets in glutamate C2 arising from 3J25 coupling provide a direct readout of acetyl-CoA fractional enrichment (FC1 and FC3), while multiplets in glutamate C5 arising from 2J35 and 3J25 couplings quantitatively reflect enrichment of the anaplerotic substrate. Magn Reson Med 42:197-200, 1999. © 1999 Wiley-Liss, Inc. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Multiple bond 13C-13C spin-spin coupling provides complementary information in a 13C NMR isotopomer analysis of glutamate | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1002/(SICI)1522-2594(199907)42:1<197 | en_US |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-1820-0353 | - |
crisitem.author.orcid | 0000-0001-7150-8301 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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