Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/8087
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Delgado, T. C. | - |
dc.contributor.author | Barosa, C. | - |
dc.contributor.author | Castro, M. M. C. A. | - |
dc.contributor.author | Geraldes, C. F. G. C. | - |
dc.contributor.author | Bastos, M. | - |
dc.contributor.author | Baptista, C. | - |
dc.contributor.author | Fagulha, A. | - |
dc.contributor.author | Barros, L. | - |
dc.contributor.author | Mota, A. | - |
dc.contributor.author | Carvalheiro, M. | - |
dc.contributor.author | Jones, J. G. | - |
dc.contributor.author | Merritt, Matthew | - |
dc.date.accessioned | 2009-02-09T11:10:48Z | - |
dc.date.available | 2009-02-09T11:10:48Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Magnetic Resonance in Medicine. 60:3 (2008) 517-523 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/8087 | - |
dc.description.abstract | The contribution of gluconeogenesis to hepatic glucose production (GP) was quantified after 2H2O ingestion by Bayesian analysis of the position 2 and 5 2H-NMR signals (H2 and H5) of monoacetone glucose (MAG) derived from urinary acetaminophen glucuronide. Six controls and 10 kidney transplant (KTx) patients with cyclosporine A (CsA) immunosuppressant therapy were studied. Seven KTx patients were lean and euglycemic (BMI = 24.3 ± 1.0 kg/m2; fasting glucose = 4.7 ± 0.1 mM) while three were obese and hyperglycemic (BMI = 30.5 ± 0.7 kg/m2; fasting glucose = 7.1 ± 0.5 mM). For the 16 spectra analyzed, the mean coefficient of variation for the gluconeogenesis contribution was 10% ± 5%. This uncertainty was associated with a mean signal-to-noise ratio (SNR) of 79:1 and 45:1 for the MAG H2 and H5 signals, respectively. For control subjects, gluconeogenesis contributed 54% ± 7% of GP as determined by the mean and standard deviation (SD) of individual Bayesian analyses. For the lean/normoglycemic KTx subjects, the gluconeogenic contribution to GP was 62% ± 7% (P = 0.06 vs. controls), while hyperglycemic/obese KTx patients had a gluconeogenic contribution of 68% ± 3% (P < 0.005 vs. controls). These data suggest that in KTx patients, an increased gluconeogenic contribution to GP is strongly associated with obesity and hyperglycemia. Magn Reson Med 60:517-523, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1002/mrm.21681 | en_US |
uc.controloAutoridade | Sim | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-6811-3878 | - |
crisitem.author.orcid | 0000-0002-0837-8329 | - |
crisitem.author.orcid | 0000-0002-3745-3885 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.