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Title: | Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples | Authors: | Manco, Licínio Machado, Patrícia Lopes, Dinora Nogueira, Fátima Rosário, Virgílio E. do Alonso, Pedro L. Varandas, Luís Trovoada, Maria de Jesus Amorim, António Arez, Ana Paula |
Issue Date: | 2009 | Publisher: | Wiley-Liss | Citation: | American Journal of Human Biology. 21:1 (2009) 118-120 | Abstract: | Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem | URI: | https://hdl.handle.net/10316/8070 | DOI: | 10.1002/ajhb.20819 | Rights: | openAccess |
Appears in Collections: | I&D CIAS - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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