Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7910
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dc.contributor.authorCarvalho, Ana Luísa-
dc.contributor.authorDuarte, Carlos B.-
dc.contributor.authorCarvalho, Arsélio P.-
dc.date.accessioned2009-02-17T10:35:58Z-
dc.date.available2009-02-17T10:35:58Z-
dc.date.issued2000en_US
dc.identifier.citationNeurochemical Research. 25:9 (2000) 1245-1255en_US
dc.identifier.urihttp://hdl.handle.net/10316/7910-
dc.description.abstractThe AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions. Recent studies have shown that phosphorylation of AMPA receptors by cAMP-dependent protein kinase (PKA) and Ca2+ - and calmodulin-dependent protein kinase II (CaMKII) potentiates their activity, but phosphorylation of the receptor subunits may also affect their interaction with intracellular proteins, and their expression at the plasma membrane. Phosphorylation of AMPA receptor subunits has also been investigated in relation to processes of synaptic plasticity. This review focuses on recent advances in understanding the molecular mechanisms of regulation of AMPA receptors, and their implications in synaptic plasticity.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleRegulation of AMPA Receptors by Phosphorylationen_US
dc.typearticleen_US
dc.identifier.doi10.1023/A:1007644128886en_US
uc.controloAutoridadeSim-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-8368-6666-
crisitem.author.orcid0000-0002-1474-0208-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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