Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/7867
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Santiago, Ana | - |
dc.contributor.author | Carvalho, Caetana | - |
dc.contributor.author | Carvalho, Arsélio | - |
dc.contributor.author | Ambrósio, António | - |
dc.date.accessioned | 2009-02-17T10:36:37Z | - |
dc.date.available | 2009-02-17T10:36:37Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Neurochemical Research. 33:8 (2008) 1501-1508 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7867 | - |
dc.description.abstract | Abstract We investigated the contribution of L-, N- and P/Q-type Ca2+ channels to the [Ca2+]i changes, evoked by kainate, in the cell bodies of hippocampal neurons, using a pharmacological approach and Ca2+ imaging. Selective Ca2+ channel blockers, namely nitrendipine, ?-Conotoxin GVIA (?-GVIA) and ?-Agatoxin IVA (?-AgaIVA) were used. The [Ca2+]i changes evoked by kainate presented a high variability, and were abolished by NBQX, a AMPA/kainate receptor antagonist, but the N-methyl-d-aspartate (NMDA) receptor antagonist, D-AP5, was without effect. Each Ca2+ channel blocker caused differential inhibitory effects on [Ca2+]i responses evoked by kainate. We grouped the neurons for each blocker in three subpopulations: (1) neurons with responses below 60% of the control; (2) neurons with responses between 60% and 90% of the control, and (3) neurons with responses above 90% of the control. The inhibition caused by nitrendipine was higher than the inhibition caused by ?-GVIA or ?-AgaIVA. Thus, in the presence of nitrendipine, the percentage of cells with responses below 60% of the control was 41%, whereas in the case of ?-GVIA or ?-AgaIVA the values were 9 or 17%, respectively. The results indicate that hippocampal neurons differ in what concerns their L-, N- and P/Q- type Ca2+ channels activated by stimulation of the AMPA/kainate receptors. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Differential Contribution of L-, N-, and P/Q-type Calcium Channels to [Ca2+]i Changes Evoked by Kainate in Hippocampal Neurons | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1007/s11064-008-9618-8 | en_US |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-0477-1641 | - |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Citações SCOPUSTM
3
Visto em 1/mai/2023
Citações WEB OF SCIENCETM
10
2
Visto em 2/out/2024
Visualizações de página
301
Visto em 15/out/2024
Downloads
375
Visto em 15/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.