Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7864
DC Field | Value | Language |
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dc.contributor.author | Marinho, Carlos | - |
dc.contributor.author | Oliveira, Catarina | - |
dc.contributor.author | Pinto-de-Barros, José | - |
dc.contributor.author | Costa-Maia, Joaquim | - |
dc.date.accessioned | 2009-02-17T10:37:59Z | - |
dc.date.available | 2009-02-17T10:37:59Z | - |
dc.date.issued | 1997 | en_US |
dc.identifier.citation | European Archives of Psychiatry and Clinical Neuroscience. 247:5 (1997) 275-277 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7864 | - |
dc.description.abstract | Abstract A cross-sectional survey was undertaken to study the aging effect on platelet cytoplasmic membrane outer leaflet fluidity and Na+/H+ antiporter activity, and to investigate the relative influence of membrane order and age on the Na+/H+ exchanger. The study population consisted of 19 healthy subjects (age range 22–83 years, mean age 48.5 ± 16.5 years; 12 females and 7 males). Washed platelets were used as neuronal models and as eventually contributing to brain pathology by aberrant secretion of their granule content. A significant positive correlation (r = 0.48,p < 0.05) was found between age and the membrane structural order, according to a second-degree equation. Sewall-Wright path coefficient analysis revealed that the age influence on Na+/H+ exchanger activity was unimportant (0.18), but those of cytoplasmic membrane outer leaflet fluidity and mean platelet volume were strong and positive (0.51 and 0.54, respectively). Women presented a marked standard deviation in the countertransporter results. In conclusion, decreased membrane outer leaflet fluidity and unchanged Na+/H+ antiporter activity may contribute to the process of normal brain aging. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Correlation between human platelet cytoplasmic membrane outer leaflet fluidity, Na+/H+ exchanger activity and aging | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1007/BF02900306 | en_US |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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