Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7575
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dc.contributor.authorGarrido, Jorge-
dc.contributor.authorMarques, M. Paula M.-
dc.contributor.authorSilva, Artur-
dc.contributor.authorMacedo, Tice-
dc.contributor.authorBrett, Ana Oliveira-
dc.contributor.authorBorges, Fernanda-
dc.date.accessioned2009-02-17T10:18:53Z-
dc.date.available2009-02-17T10:18:53Z-
dc.date.issued2007en_US
dc.identifier.citationAnalytical and Bioanalytical Chemistry. 388:8 (2007) 1799-1808en_US
dc.identifier.urihttp://hdl.handle.net/10316/7575-
dc.description.abstractAbstract The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine–opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug–drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine–morphine mixture (C–MH), formation of a binary complex was detected; this involved the 3-phenolic group and the heterocyclic oxygen of morphine and the carbonyl oxygen and the methyl protons of cocaine’s methyl ester group. NMR studies conducted simultaneously also revealed C–MH binding geometry consistent with theoretical predictions and with electrochemical and vibrational spectroscopy results. These results provide evidence for the occurrence of a cocaine–morphine interaction, both in the solid state and in solution, particularly for the hydrochloride form. A slight interaction, in solution, was also detected by NMR for the cocaine–heroin mixture. Figure "Schematic representation of the proposed model for cocaine:morphine salt interaction"en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleSpectroscopic and electrochemical studies of cocaine–opioid interactionsen_US
dc.typearticleen_US
dc.identifier.doi10.1007/s00216-007-1375-zen_US
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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