Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5835
Title: Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity
Authors: Coleta, Miguel 
Campos, Maria Graça 
Cotrim, Maria Dulce 
Lima, Thereza Christina M. de 
Cunha, António Proença da 
Keywords: Luteolin; Flavonoids; Flavones; Central nervous system; Anxiolytics
Issue Date: 2008
Citation: Behavioural Brain Research. 189:1 (2008) 75-82
Abstract: Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABAA receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Luteolin (3',4',5,7-tetrahydroxyflavone) is a widespread flavonoid aglycon that was reported as devoid of specific affinity for benzodiazepine receptor (BDZ-R) binding site, but its psychopharmacological activity is presently unknown. Considering (1) the close structural similarity with other active flavones, (2) the activity of some of its glycosilated derivatives and (3) the complexity of flavonoid effects in the central nervous system, luteolin was submitted to a battery of tests designed to evaluate its possible activity upon the CNS and its ability to interact with the BDZ-receptor binding sites was also analysed.
URI: http://hdl.handle.net/10316/5835
DOI: 10.1016/j.bbr.2007.12.010
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
file4cf24c5de56c451faf37103c33f52aec.pdf862.09 kBAdobe PDFView/Open
Show full item record

WEB OF SCIENCETM
Citations

77
checked on Aug 2, 2022

Page view(s) 50

533
checked on Aug 4, 2022

Download(s) 50

404
checked on Aug 4, 2022

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.