Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5813
Title: Enthalpy of solution of terfenadine in ethanol/water mixtures
Authors: Canotilho, João 
Costa, Felisbela S. 
Sousa, Adriano T. 
Redinha, J. Simões 
Leitão, M. Luísa P. 
Keywords: Crystal design; Crystallization; Polymorphism; Solubility; Solute self-aggregation; Solution enthalpy; Terfenadine
Issue Date: 2000
Citation: Thermochimica Acta. 344:1-2 (2000) 9-13
Abstract: The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined.
URI: http://hdl.handle.net/10316/5813
DOI: 10.1016/s0040-6031(99)00319-6
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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