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Title: Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations
Authors: Felix, Fabiana S. 
Brett, Christopher M. A. 
Angnes, Lúcio 
Keywords: Flow injection analysis; Carbon film resistor electrodes; Acetaminophen; Amperometry
Issue Date: 2007
Citation: Journal of Pharmaceutical and Biomedical Analysis. 43:5 (2007) 1622-1627
Abstract: Flow injection analysis (FIA) with amperometric detection was employed for acetaminophen quantification in pharmaceutical formulations using a carbon film resistor electrode. This sensor exhibited sharp and reproducible current peaks for acetaminophen without chemical modification of its surface. A wide linear working range (8.0 × 10-7 to 5.0 × 10-4 mol L-1) in phosphate buffer solution as well as high sensitivity (0.143 A mol-1 L cm-2) and low submicromolar detection limit (1.36 × 10-7 mol L-1) were achieved. The repeatability (R.S.D. for 10 successive injections of 5.0 × 10-6 and 5.0 × 10-5 mol L-1 acetaminophen solutions) was 3.1 and 1.3%, respectively, without any memory effect between injections. The new procedure was applied to the analyses of commercial pharmaceutical products and the results were in good agreement with those obtained utilizing a spectrophotometric method. Consequently, this amperometric method has been shown to be very suitable for quality control analyses and other applications with similar requirements.
DOI: 10.1016/j.jpba.2006.11.038
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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