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https://hdl.handle.net/10316/5049
Title: | Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations | Authors: | Felix, Fabiana S. Brett, Christopher M. A. Angnes, Lúcio |
Keywords: | Flow injection analysis; Carbon film resistor electrodes; Acetaminophen; Amperometry | Issue Date: | 2007 | Citation: | Journal of Pharmaceutical and Biomedical Analysis. 43:5 (2007) 1622-1627 | Abstract: | Flow injection analysis (FIA) with amperometric detection was employed for acetaminophen quantification in pharmaceutical formulations using a carbon film resistor electrode. This sensor exhibited sharp and reproducible current peaks for acetaminophen without chemical modification of its surface. A wide linear working range (8.0 × 10-7 to 5.0 × 10-4 mol L-1) in phosphate buffer solution as well as high sensitivity (0.143 A mol-1 L cm-2) and low submicromolar detection limit (1.36 × 10-7 mol L-1) were achieved. The repeatability (R.S.D. for 10 successive injections of 5.0 × 10-6 and 5.0 × 10-5 mol L-1 acetaminophen solutions) was 3.1 and 1.3%, respectively, without any memory effect between injections. The new procedure was applied to the analyses of commercial pharmaceutical products and the results were in good agreement with those obtained utilizing a spectrophotometric method. Consequently, this amperometric method has been shown to be very suitable for quality control analyses and other applications with similar requirements. | URI: | https://hdl.handle.net/10316/5049 | DOI: | 10.1016/j.jpba.2006.11.038 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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