Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5049
DC Field | Value | Language |
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dc.contributor.author | Felix, Fabiana S. | - |
dc.contributor.author | Brett, Christopher M. A. | - |
dc.contributor.author | Angnes, Lúcio | - |
dc.date.accessioned | 2008-09-01T15:03:04Z | - |
dc.date.available | 2008-09-01T15:03:04Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Journal of Pharmaceutical and Biomedical Analysis. 43:5 (2007) 1622-1627 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5049 | - |
dc.description.abstract | Flow injection analysis (FIA) with amperometric detection was employed for acetaminophen quantification in pharmaceutical formulations using a carbon film resistor electrode. This sensor exhibited sharp and reproducible current peaks for acetaminophen without chemical modification of its surface. A wide linear working range (8.0 × 10-7 to 5.0 × 10-4 mol L-1) in phosphate buffer solution as well as high sensitivity (0.143 A mol-1 L cm-2) and low submicromolar detection limit (1.36 × 10-7 mol L-1) were achieved. The repeatability (R.S.D. for 10 successive injections of 5.0 × 10-6 and 5.0 × 10-5 mol L-1 acetaminophen solutions) was 3.1 and 1.3%, respectively, without any memory effect between injections. The new procedure was applied to the analyses of commercial pharmaceutical products and the results were in good agreement with those obtained utilizing a spectrophotometric method. Consequently, this amperometric method has been shown to be very suitable for quality control analyses and other applications with similar requirements. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6TGX-4MSHT96-1/1/a5eb87f817e43c4bd0120021afa851f3 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Flow injection analysis | en_US |
dc.subject | Carbon film resistor electrodes | en_US |
dc.subject | Acetaminophen | en_US |
dc.subject | Amperometry | en_US |
dc.title | Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.jpba.2006.11.038 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-1972-4434 | - |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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filebfb23f8622474875acd3009509ea2c52.pdf | 598.85 kB | Adobe PDF | View/Open |
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