Title: Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents
Authors: Ferreira, Fernanda M. 
Seiça, Raquel 
Oliveira, Paulo J. 
Coxito, Pedro M. 
Moreno, António J. 
Palmeira, Carlos M. 
Santos, Maria S. 
Keywords: Diabetes mellitus;Type 1 diabetes;Type 2 diabetes;Goto-Kakizaki (GK) rat;Streptozotocin-induced diabetic (STZ) rat;Mitochondrial permeability transition (MPT)
Issue Date: 2003
Citation: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1639:2 (2003) 113-120
Abstract: Several studies have been carried out to evaluate the alterations in mitochondrial functions of diabetic rats. However, results are sometimes controversial, since experimental conditions diverge, including age and strain of used animals. The purpose of this study was to evaluate the metabolic modifications in liver mitochondria, both in the presence of severe (STZ-treated rats) and mild hyperglycaemia [Goto-Kakizaki (GK) rats], when compared with control animals of similar age. Moreover, metabolic alterations were evaluated also at initial and advanced stages of the disease.
URI: http://hdl.handle.net/10316/4799
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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