Title: Co-infection with HIV associated with reduced vulnerability to symptoms of depression during antiviral treatment for hepatitis C
Authors: Fialho, Renata 
Pereira, Marco 
Harrison, Neil 
Rusted, Jennifer 
Whale, Richard 
Keywords: Adult;Antiviral Agents;Coinfection;Depressive Disorder, Major;Drug Therapy, Combination;Female;HIV Infections;Hepacivirus;Hepatitis C;Humans;Interferon-alpha;Male;Middle Aged;Prospective Studies;Ribavirin
Issue Date: 2017
Citation: Fialho, R., Pereira, M., Harrison, N., Rusted, J., & Whale, R. (2017). Co-infection with HIV associated with reduced vulnerability to symptoms of depression during antiviral treatment for hepatitis C. Psychiatry Research, 253, 150-157. doi:10.1016/j.psychres.2017.03.049
Abstract: In this prospective study, we examined new-onset major depressive disorder (MDD) and the differential expression of depressive symptoms in a sample of 132 HCV mono-infected and 40 HIV/HCV co-infected patients initiating pegylated interferon-based treatment, including protease inhibitor therapy. The semi-structured clinical interview (SCID-I) was used to assess MDD. Severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Of the total sample, 60 patients (34.9%) developed SCID-I defined MDD during antiviral treatment. The proportion of HCV mono- and HIV/HCV patients developing MDD during treatment was not significantly different (37.9% vs. 25%; p=0.185). In both groups, there was a significant increase in HAMD total score from baseline to week 4, and a significant decrease between week 24 and 6 months post-treatment cessation. The greatest increase was observed in the symptoms of the neurovegetative syndrome. HCV mono-infected patients reported higher scores than co-infected patients, particularly impaired activity and somatic symptoms, but the differences were only significant at week 12. The finding that co-infected patients appear less vulnerable to the development of depressive symptoms during HCV treatment than HCV mono-infected patients warrants further exploration, including a thorough analysis of the biological and psychosocial factors associated with this emergence.
URI: http://hdl.handle.net/10316/47395
DOI: 10.1016/j.psychres.2017.03.049
Rights: openAccess
Appears in Collections:FPCEUC - Artigos em Revistas Internacionais

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