Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/46910
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dc.contributor.authorLobo, Lis-
dc.contributor.authorSousa, Bruno de-
dc.contributor.authorCabral, Lília-
dc.contributor.authorCristiano, Maria L. S.-
dc.contributor.authorNogueira, Fátima-
dc.date.accessioned2018-01-26T18:22:45Z-
dc.date.available2018-01-26T18:22:45Z-
dc.date.issued2016-
dc.identifier.urihttp://hdl.handle.net/10316/46910-
dc.description.abstractEver increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy. In the absence of licensed vaccines, treatment and prevention of malaria is heavily dependent on drugs. Potency, range of activity, safety, low cost and ease of administration are crucial issues in the design and formulation of antimalarials. We have tested three synthetic ozonides NAC89, LC50 and LCD67 in vitro and in vivo against multidrug resistant Plasmodium. In vitro, LC50 was at least 10 times more efficient inhibiting P. falciparum multidrug resistant Dd2 strain than chloroquine and mefloquine and as efficient as artemisinin (ART), artesunate and dihydroartemisinin. All three ozonides showed high efficacy in clearing parasitaemia in mice, caused by multi-drug resistant Plasmodium chabaudi strains, by subcutaneous administration, demonstrating high efficacy in vivo against ART and artesunate resistant parasites.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnimalspor
dc.subjectAntimalarialspor
dc.subjectArtemisininspor
dc.subjectChloroquinepor
dc.subjectDisease Models, Animalpor
dc.subjectFemalepor
dc.subjectHumanspor
dc.subjectMalaria, Falciparumpor
dc.subjectMefloquinepor
dc.subjectMicepor
dc.subjectParasitemiapor
dc.subjectPlasmodium falciparumpor
dc.titleHighly active ozonides selected against drug resistant malariapor
dc.typearticlepor
degois.publication.firstPage450por
degois.publication.lastPage453por
degois.publication.issue7por
degois.publication.titleMemórias do Instituto Oswaldo Cruzpor
dc.identifier.doi10.1590/0074-02760160077-
degois.publication.volume111por
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.researchunitCenter for Research in Neuropsychology and Cognitive Behavioral Intervention-
crisitem.author.orcid0000-0001-9918-8100-
Appears in Collections:I&D CINEICC - Artigos em Revistas Internacionais
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