Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45155
DC FieldValueLanguage
dc.contributor.authorGomes, Catarina A.-
dc.contributor.authorCruz, Teresa Girão da-
dc.contributor.authorAndrade, José L.-
dc.contributor.authorMilhazes, Nuno-
dc.contributor.authorBorges, Fernanda-
dc.contributor.authorMarques, M. Paula M.-
dc.date.accessioned2017-12-15T18:58:47Z-
dc.date.available2017-12-15T18:58:47Z-
dc.date.issued2003-
dc.identifier.urihttp://hdl.handle.net/10316/45155-
dc.description.abstractSeveral phenolic acids-caffeic and gallic acid derivatives-were synthesized and screened for their potential antiproliferative and cytotoxic properties, in different human cancer cell lines: mammary gland and cervix adenocarcinomas and lymphoblastic leukemia. The selected phenols were structurally related, which allowed us to gather important information regarding the structure-activity relationships underlying the biological activity of such compounds. This is proposed to be due to a balance between the antioxidant and pro-oxidant properties of this kind of agent. Distinct effects were found for different cell lines, which points to a significant specificity of action of the drugs tested. It was verified, for the types of cancer investigated, that the trihydroxylated derivatives yielded better results than the dihydroxylated ones. Tests in noncancerous cells, human lung fibroblasts, were also undertaken, in view of determining the toxic side effects of the compounds studied.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAdenocarcinomapor
dc.subjectAntineoplastic Agentspor
dc.subjectBreast Neoplasmspor
dc.subjectCaffeic Acidspor
dc.subjectCell Divisionpor
dc.subjectCell Line, Tumorpor
dc.subjectCell Survivalpor
dc.subjectDrug Screening Assays, Antitumorpor
dc.subjectFemalepor
dc.subjectGallic Acidpor
dc.subjectHumanspor
dc.subjectLeukemia, Lymphoidpor
dc.subjectMagnetic Resonance Spectroscopypor
dc.subjectModels, Molecularpor
dc.subjectMolecular Conformationpor
dc.subjectPhenolspor
dc.subjectSpectrometry, Mass, Electrospray Ionizationpor
dc.subjectSpectrophotometry, Ultravioletpor
dc.subjectSpectroscopy, Fourier Transform Infraredpor
dc.subjectStructure-Activity Relationshippor
dc.subjectUterine Cervical Neoplasmspor
dc.titleAnticancer Activity of Phenolic Acids of Natural or Synthetic Origin:  A Structure−Activity Studypor
dc.typearticle-
degois.publication.firstPage5395por
degois.publication.lastPage5401por
degois.publication.issue25por
degois.publication.titleJournal of Medicinal Chemistrypor
dc.peerreviewedyespor
dc.identifier.doi10.1021/jm030956v-
dc.identifier.doi10.1021/jm030956vpor
degois.publication.volume46por
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0003-2625-2567-
crisitem.author.orcid0000-0002-5171-0454-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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