Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45150
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dc.contributor.authorFiuza, S. M.-
dc.contributor.authorGomes, C.-
dc.contributor.authorTeixeira, L. J.-
dc.contributor.authorGirão da Cruz, M. T.-
dc.contributor.authorCordeiro, M. N. D. S.-
dc.contributor.authorMilhazes, N.-
dc.contributor.authorBorges, F.-
dc.contributor.authorMarques, M. P. M.-
dc.date.accessioned2017-12-15T18:54:10Z-
dc.date.available2017-12-15T18:54:10Z-
dc.date.issued2004-
dc.identifier.urihttp://hdl.handle.net/10316/45150-
dc.description.abstractThe antiproliferative and cytotoxic properties of polyphenolic acid derivatives, structurally related with the natural models caffeic and gallic acids, have been tested in human cervix adenocarcinoma cells (HeLa). Simultaneous structural information was obtained for these compounds through theoretical ab initio methods. This study was conducted for the following esters: methyl caffeate (MC, 1), propyl caffeate (PC, 2), octyl caffeate (OC, 3), methyl gallate (MG, 4), propyl gallate (PG, 5) and octyl gallate (OG, 6). A significant growth-inhibition effect was assessed for some of these compounds, clearly dependent on their structural characteristics. Marked structure-activity relationships (SARs)--namely the number of hydroxyl ring substituents--were found to rule the biological effect of such systems.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAntineoplastic Agentspor
dc.subjectCaffeic Acidspor
dc.subjectCell Linepor
dc.subjectCell Survivalpor
dc.subjectDrug Screening Assays, Antitumorpor
dc.subjectEsterspor
dc.subjectGallic Acidpor
dc.subjectHumanspor
dc.subjectHydroxybenzoatespor
dc.subjectInhibitory Concentration 50por
dc.subjectMethylationpor
dc.subjectMolecular Structurepor
dc.subjectStructure-Activity Relationshippor
dc.titlePhenolic acid derivatives with potential anticancer properties––a structure–activity relationship study. Part 1: Methyl, propyl and octyl esters of caffeic and gallic acidspor
dc.typearticle-
degois.publication.firstPage3581por
degois.publication.lastPage3589por
degois.publication.issue13por
degois.publication.titleBioorganic & Medicinal Chemistrypor
dc.peerreviewedyespor
dc.identifier.doi10.1016/j.bmc.2004.04.026por
dc.identifier.doi10.1016/j.bmc.2004.04.026-
degois.publication.volume12por
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-5171-0454-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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