Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45107
DC FieldValueLanguage
dc.contributor.authorTassoni, Annalisa-
dc.contributor.authorBagni, Nello-
dc.contributor.authorFerri, Maura-
dc.contributor.authorFranceschetti, Marina-
dc.contributor.authorKhomutov, Alex-
dc.contributor.authorMarques, Maria Paula-
dc.contributor.authorFiuza, Sónia M.-
dc.contributor.authorSimonian, Alina R.-
dc.contributor.authorSerafini-Fracassini, Donatella-
dc.date.accessioned2017-12-15T18:02:21Z-
dc.date.available2017-12-15T18:02:21Z-
dc.date.issued2010-
dc.identifier.urihttp://hdl.handle.net/10316/45107-
dc.description.abstractThe earliest studies concerning polyamines (PAs) in plants were performed by using in vitro cultured explants of Helianthus tuberosus dormant tuber. This parenchyma tissue was particularly useful due to its susceptibility to several growth substances, including PAs. During tuber dormancy, PA levels are too low to sustain cell division; thus Helianthus represents a natural PA-deficient model. When cultivated in vitro in the presence of auxins, Helianthus tuber dormant parenchyma cells at the G(0) stage start to divide synchronously acquiring meristematic characteristics. The requirement for auxins to induce cell division can be substituted by aliphatic PAs such as putrescine, spermidine or spermine. Cylinders or slices of explanted homogeneous tuber parenchyma were cultured in liquid medium for short-term studies on the cell cycle, or on solid agar medium for long-term experiments. Morphological and physiological modifications of synchronously dividing cells were studied during the different phases of the cell cycle in relation to PAs biosynthesis and oxidation. Long-term experiments led to the identification of the PAs as plant growth regulators, as the sole nitrogen source, as tuber storage substances and as essential factors for morphogenetic processes and cell homeostasis. More recently this system was used to study the effects on plant cell proliferation of platinum- or palladium-derived drugs (cisplatin and platinum or palladium bi-substituted spermine) that are used in human cancer cell lines as antiproliferative and cytotoxic agents. Cisplatin was the most active both in cell proliferation inhibition and on PA metabolism. Similar experiments were performed using three agmatine analogous. Different effects of these compounds were observed on cell proliferation, free PA levels and enzyme activities, leading to a hypothesis of a correlation between their chemical structure and the agmatine metabolism in plants.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAgmatinepor
dc.subjectAnimalspor
dc.subjectAntineoplastic Agentspor
dc.subjectCell Divisionpor
dc.subjectCell Proliferationpor
dc.subjectHelianthuspor
dc.subjectHumanspor
dc.subjectNeoplasmspor
dc.subjectPalladiumpor
dc.subjectPlant Growth Regulatorspor
dc.subjectPlatinum Compoundspor
dc.subjectPolyaminespor
dc.titleHelianthus tuberosus and polyamine research: Past and recent applications of a classical growth modelpor
dc.typearticle-
degois.publication.firstPage496por
degois.publication.lastPage505por
degois.publication.issue7por
degois.publication.titlePlant Physiology and Biochemistrypor
dc.peerreviewedyespor
dc.identifier.doi10.1016/j.plaphy.2010.01.019por
dc.identifier.doi10.1016/j.plaphy.2010.01.019-
degois.publication.volume48por
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
PPB_10_48.pdf1.48 MBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

20
checked on Feb 18, 2020

WEB OF SCIENCETM
Citations 5

21
checked on Dec 2, 2021

Page view(s)

225
checked on Nov 25, 2021

Download(s)

220
checked on Nov 25, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.