Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45089
Title: Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis
Authors: Silva, T.M. 
Oredsson, S. 
Persson, L. 
Woster, P. 
Marques, M. P. M. 
Keywords: Antineoplastic Agents; Palladium; Platinum; Platinum Compounds; Polyamines; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman
Issue Date: 2012
Serial title, monograph or event: Journal of Inorganic Biochemistry
Volume: 108
Abstract: A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.
URI: http://hdl.handle.net/10316/45089
DOI: 10.1016/j.jinorgbio.2011.11.021
10.1016/j.jinorgbio.2011.11.021
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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