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https://hdl.handle.net/10316/41710
Title: | Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents | Authors: | Pereira, Nelson A. M. Laranjo, Mafalda Casalta-Lopes, João Serra, Arménio C. Piñeiro, Marta Pina, João Seixas de Melo, J. Sérgio Senge, Mathias O. Botelho, M. Filomena Martelo, Liliana Burrows, Hugh D. Pinho e Melo, Teresa M. V. D. |
Issue Date: | 2017 | Serial title, monograph or event: | ACS Medicinal Chemistry Letters | Volume: | 8 | Issue: | 3 | Abstract: | Novel near-infrared luminescent compounds based on platinum(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins are described. These compounds have high photostability and display light emission, in particular simultaneous fluorescence and phosphorescence emission in solution at room temperature, in the biologically relevant 700-850 nm red and near-infrared (NIR) spectral region, making them excellent materials for biological imaging. The simultaneous presence of fluorescence and phosphorescence emission at room temperature, with the phosphorescence strongly quenched by oxygen whereas fluorescence remains unaffected, allows these compounds to be used as ratiometric oxygen sensors in chemical and biological media. Both steady-state (fluorescence vs phosphorescence intensities) and dynamic (dependence of phosphorescence lifetimes upon oxygen concentration) luminescence approaches can be used. Photocytotoxicity studies against human melanocytic melanoma cells (A375) indicate that these compounds display potential as photosensitizers in photodynamic therapy. | URI: | https://hdl.handle.net/10316/41710 | DOI: | 10.1021/acsmedchemlett.6b00476 | Rights: | embargoedAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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