Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/41710
Title: Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents
Authors: Pereira, Nelson A. M. 
Laranjo, Mafalda 
Casalta-Lopes, João 
Serra, Arménio C. 
Piñeiro, Marta 
Pina, João 
Seixas de Melo, J. Sérgio 
Senge, Mathias O. 
Botelho, M. Filomena 
Martelo, Liliana 
Burrows, Hugh D. 
Pinho e Melo, Teresa M. V. D. 
Issue Date: 2017
Serial title, monograph or event: ACS Medicinal Chemistry Letters
Volume: 8
Issue: 3
Abstract: Novel near-infrared luminescent compounds based on platinum(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins are described. These compounds have high photostability and display light emission, in particular simultaneous fluorescence and phosphorescence emission in solution at room temperature, in the biologically relevant 700-850 nm red and near-infrared (NIR) spectral region, making them excellent materials for biological imaging. The simultaneous presence of fluorescence and phosphorescence emission at room temperature, with the phosphorescence strongly quenched by oxygen whereas fluorescence remains unaffected, allows these compounds to be used as ratiometric oxygen sensors in chemical and biological media. Both steady-state (fluorescence vs phosphorescence intensities) and dynamic (dependence of phosphorescence lifetimes upon oxygen concentration) luminescence approaches can be used. Photocytotoxicity studies against human melanocytic melanoma cells (A375) indicate that these compounds display potential as photosensitizers in photodynamic therapy.
URI: https://hdl.handle.net/10316/41710
DOI: 10.1021/acsmedchemlett.6b00476
Rights: embargoedAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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