Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/41710
DC FieldValueLanguage
dc.contributor.authorPereira, Nelson A. M.-
dc.contributor.authorLaranjo, Mafalda-
dc.contributor.authorCasalta-Lopes, João-
dc.contributor.authorSerra, Arménio C.-
dc.contributor.authorPiñeiro, Marta-
dc.contributor.authorPina, João-
dc.contributor.authorSeixas de Melo, J. Sérgio-
dc.contributor.authorSenge, Mathias O.-
dc.contributor.authorBotelho, M. Filomena-
dc.contributor.authorMartelo, Liliana-
dc.contributor.authorBurrows, Hugh D.-
dc.contributor.authorPinho e Melo, Teresa M. V. D.-
dc.date.accessioned2017-06-02T10:21:24Z-
dc.date.issued2017-
dc.identifier.urihttp://hdl.handle.net/10316/41710-
dc.description.abstractNovel near-infrared luminescent compounds based on platinum(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins are described. These compounds have high photostability and display light emission, in particular simultaneous fluorescence and phosphorescence emission in solution at room temperature, in the biologically relevant 700-850 nm red and near-infrared (NIR) spectral region, making them excellent materials for biological imaging. The simultaneous presence of fluorescence and phosphorescence emission at room temperature, with the phosphorescence strongly quenched by oxygen whereas fluorescence remains unaffected, allows these compounds to be used as ratiometric oxygen sensors in chemical and biological media. Both steady-state (fluorescence vs phosphorescence intensities) and dynamic (dependence of phosphorescence lifetimes upon oxygen concentration) luminescence approaches can be used. Photocytotoxicity studies against human melanocytic melanoma cells (A375) indicate that these compounds display potential as photosensitizers in photodynamic therapy.por
dc.language.isoengpor
dc.relationThis work was funded by FEDER - Fundo Europeu de Desenvolvimento Regional through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia in the framework of the project POCI-01-0145-FEDER-PTDC/QEQ- MED/0262/2014.), Portuguese Agency for Scientific Research. The Coimbra Chemistry Centre (CQC) is supported by FCT through project no 007630 UID/QUI/00313/2013, co-funded by COMPETE2020-UE. The FCT is also acknowledged for a post-doctoral grant to J. Pina (ref. SFRH/BPD/108469/2015). We acknowledge the UC-NMR facility for obtaining the NMR data (www.nmrccc.uc.pt), and Professor Mário N. Berberan- Santos (Instituto Superior Técnico) for valuable discussions The authors also gratefully acknowledge Perkin-Helmer, Inc. and Intrumentos de Laboratório Científico, Lda (ILC) for providing the EnSpire Multimode Plate Reader and Dr. Hans-Peter Steffens (Perkin-Helmer, Inc) for technical support. MOS acknowledges grant SFI IvP 13/1894.por
dc.rightsembargoedAccess-
dc.titlePlatinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agentspor
dc.typearticle-
degois.publication.firstPage310por
degois.publication.lastPage315por
degois.publication.issue3por
degois.publication.titleACS Medicinal Chemistry Letterspor
dc.identifier.doi10.1021/acsmedchemlett.6b00476-
degois.publication.volume8por
dc.date.embargo2018-06-02T10:21:24Z-
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-1891-9010-
crisitem.author.orcid0000-0003-0689-6007-
crisitem.author.orcid0000-0001-8664-2757-
crisitem.author.orcid0000-0002-7460-3758-
crisitem.author.orcid0000-0003-1848-1167-
crisitem.author.orcid0000-0001-9708-5079-
crisitem.author.orcid0000-0001-7202-1650-
crisitem.author.orcid0000-0003-3127-2298-
crisitem.author.orcid0000-0003-3256-4954-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
ACSMedChemLett Post print.pdf537.74 kBAdobe PDFView/Open
Show simple item record

WEB OF SCIENCETM
Citations

30
checked on Sep 2, 2021

Page view(s)

203
checked on Sep 24, 2021

Download(s)

201
checked on Sep 24, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.