Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/3886
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tomé, Ângelo R. | - |
dc.contributor.author | Izaguirre, Victor | - |
dc.contributor.author | Rosário, Luís M. | - |
dc.contributor.author | Ceña, Valentín | - |
dc.contributor.author | González-García, Carmen | - |
dc.date.accessioned | 2008-08-29T15:35:37Z | - |
dc.date.available | 2008-08-29T15:35:37Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Brain Research. 903:1-2 (2001) 62-65 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/3886 | - |
dc.description.abstract | Nicotine-induced catecholamine (CA) secretion and inward ionic currents were inhibited by the opioid antagonist naloxone in cultured bovine chromaffin cells. Naloxone inhibited nicotine-induced CA secretion, as detected by an on-line real-time electrochemical technique, in a dose-dependent manner (IC50=29 [mu]M). In voltage-clamped chromaffin cells, nicotine (10 [mu]M) evoked an average peak inward current of -146 pA that was inhibited by low concentrations of naloxone (42% at 0.1 [mu]M). The antagonist also inhibited total charge influx associated with nicotinic receptor activation (53% at 0.1 [mu]M). This provides strong evidence that naloxone modulation of nicotine-induced CA secretion does not involve opioid receptors but results from the direct interaction with the nicotinic receptor itself, which might also be the case for other related opioid compounds. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6SYR-43MC9YT-C/1/1994796a9d2862757ab52186bcacc5f6 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Opioids | en_US |
dc.subject | Nicotinic receptor | en_US |
dc.subject | Currents | en_US |
dc.subject | Catecholamine secretion | en_US |
dc.subject | Patch-clamp | en_US |
dc.title | Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/S0006-8993(01)02388-5 | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8671-989X | - |
crisitem.author.orcid | 0000-0001-8329-2333 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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filef62fb0ccd06b4f719e7db5f5ee217ed3.pdf | 75.36 kB | Adobe PDF | View/Open |
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