Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/3886
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dc.contributor.authorTomé, Ângelo R.-
dc.contributor.authorIzaguirre, Victor-
dc.contributor.authorRosário, Luís M.-
dc.contributor.authorCeña, Valentín-
dc.contributor.authorGonzález-García, Carmen-
dc.date.accessioned2008-08-29T15:35:37Z-
dc.date.available2008-08-29T15:35:37Z-
dc.date.issued2001en_US
dc.identifier.citationBrain Research. 903:1-2 (2001) 62-65en_US
dc.identifier.urihttp://hdl.handle.net/10316/3886-
dc.description.abstractNicotine-induced catecholamine (CA) secretion and inward ionic currents were inhibited by the opioid antagonist naloxone in cultured bovine chromaffin cells. Naloxone inhibited nicotine-induced CA secretion, as detected by an on-line real-time electrochemical technique, in a dose-dependent manner (IC50=29 [mu]M). In voltage-clamped chromaffin cells, nicotine (10 [mu]M) evoked an average peak inward current of -146 pA that was inhibited by low concentrations of naloxone (42% at 0.1 [mu]M). The antagonist also inhibited total charge influx associated with nicotinic receptor activation (53% at 0.1 [mu]M). This provides strong evidence that naloxone modulation of nicotine-induced CA secretion does not involve opioid receptors but results from the direct interaction with the nicotinic receptor itself, which might also be the case for other related opioid compounds.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6SYR-43MC9YT-C/1/1994796a9d2862757ab52186bcacc5f6en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectOpioidsen_US
dc.subjectNicotinic receptoren_US
dc.subjectCurrentsen_US
dc.subjectCatecholamine secretionen_US
dc.subjectPatch-clampen_US
dc.titleNaloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cellsen_US
dc.typearticleen_US
dc.identifier.doi10.1016/S0006-8993(01)02388-5-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-8671-989X-
crisitem.author.orcid0000-0001-8329-2333-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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