Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/34023
DC FieldValueLanguage
dc.contributor.authorMarques, M. Paula M.-
dc.contributor.authorValero, Rosendo-
dc.contributor.authorParker, Stewart F.-
dc.contributor.authorTomkinson, John-
dc.contributor.authorCarvalho, Luís A. E. Batista de-
dc.date.accessioned2016-12-22T10:46:27Z-
dc.date.available2016-12-22T10:46:27Z-
dc.date.issued2013-
dc.identifier.urihttps://hdl.handle.net/10316/34023-
dc.description.abstractThis study reports a combined experimental and theoretical study of the solid-state polymorphism of the anticancer agent cisplatin. A complete assignment was performed for the inelastic neutron scattering (INS) and Raman spectra collected simultaneously for cisplatin, at different temperatures, with a view to obtain reliable and definitive evidence of the relative thermal stability of its α and β polymorphic species. A marked temperature-dependent hysteresis was observed, as previously reported in the literature. Theoretical calculations were carried out at the density functional theory level, using a plane-wave basis set approach and pseudopotentials. A detailed comparison with the experimental Raman and INS data showed that the α polymorph is present at the lowest temperatures, whereas the β form occurs near room temperature. Furthermore, regions of coexistence of both forms are identified, which depend on the working mode (heating or cooling). These findings imply that Raman spectroscopy allows clear identification of the α and β polymorphs at a given temperature and can unambiguously discriminate between them. Elucidation of the polymorphic equilibrium of this widely used anticancer drug is paramount for its pharmaceutical preparation and storage conditions.por
dc.language.isoporpor
dc.rightsopenAccesspor
dc.subjectAntineoplastic Agentspor
dc.subjectCisplatinpor
dc.subjectModels, Molecularpor
dc.subjectSpectrum Analysis, Ramanpor
dc.subjectTemperaturepor
dc.titlePolymorphism in Cisplatin Anticancer Drugpor
dc.typearticle-
degois.publication.firstPage6421por
degois.publication.lastPage6429por
degois.publication.issue21por
degois.publication.titleThe Journal of Physical Chemistry Bpor
dc.peerreviewedyespor
dc.identifier.doi10.1021/jp403486z-
degois.publication.volume117por
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.languageiso639-1pt-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-8391-0055-
crisitem.author.orcid0000-0002-8059-8537-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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