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Title: The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease
Authors: Plácido, A. I. 
Pereira, C. M. F. 
Duarte, A. I. 
Candeias, E. 
Correia, S. C. 
Santos, R. X. 
Carvalho, C. 
Cardoso, S. 
Oliveira, C. R. 
Moreira, P. I. 
Keywords: Alzheimer's disease; Amyloid precursor protein; Endoplasmic reticulum; Secretory pathway; Therapeutic targets; Trafficking
Issue Date: Sep-2014
Publisher: Elsevier
Citation: PLÁCIDO, A. I. [et. al] - The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease. "Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease". ISSN 0925-4439. Vol. 1842 Nº. 9 (2014) p. 1444–1453
Serial title, monograph or event: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume: 1842
Issue: 9
Abstract: The endoplasmic reticulum (ER) is the principal organelle responsible for the proper folding/processing of nascent proteins and perturbed ER function leads to a state known as ER stress. Mammalian cells try to overcome ER stress through a set of protein signaling pathways and transcription factors termed the unfolded protein response (UPR). However, under unresolvable ER stress conditions, the UPR is hyperactivated inducing cell dysfunction and death. The accumulation of misfolded proteins in the brain of Alzheimer's disease (AD) patients suggests that alterations in ER homeostasis might be implicated in the neurodegenerative events that characterize this disorder. This review discusses the involvement of ER stress in the pathogenesis of AD, focusing the processing and trafficking of the AD-related amyloid precursor protein (APP) during disease development. The potential role of ER as a therapeutic target in AD will also be debated.
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2014.05.003
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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