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Title: Carbon dots from tryptophan doped glucose for peroxynitrite sensing
Authors: Simões, Eliana F. C. 
Silva, Joaquim C. G. Esteves da 
Leitão, João M. M. 
Keywords: Carbon dots; Tryptophan; Peroxynitrite; Sensing; Fluorescence quenching
Issue Date: 10-Dec-2014
Publisher: Elsevier
Citation: SIMÕES, Eliana F. C.; SILVA, Joaquim C. G. Esteves da; LEITÃO, João M. M. - Carbon dots from tryptophan doped glucose for peroxynitrite sensing. "Analytica Chimica Acta". ISSN 0003-2670. Vol. 852 (2014) p. 174–180
Serial title, monograph or event: Analytica Chimica Acta
Volume: 852
Abstract: Tryptophan doped carbon dots (Trp-CD) were microwave synthesized. The optimum conditions of synthesizing of the Trp-CD were established by response surface multivariate optimization methodologies and were the following: 2.5 g of glucose and 300 mg of tryptophan diluted in 15 mL of water exposed for 5 min to a microwave radiation of 700 W. Trp-CD have an average size of 20 nm, were fluorescent with a quantum yield of 12.4% and the presence of peroxynitrite anion (ONOO−) provokes quenching of the fluorescence. The evaluated analytical methodology for ONOO− detection shows a linear response range from 5 to 25 μM with a limit of detection of 1.5 μM and quantification of 4.9 μM. The capability of the ONOO− quantification was evaluated in standard solutions and in fortified serum samples.
ISSN: 0003-2670
DOI: 10.1016/j.aca.2014.08.050
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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