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https://hdl.handle.net/10316/27237
Title: | Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice | Authors: | Jr., A. S. Aguiar Moreira, E. L. G. Hoeller, A. A. Oliveira, P. A. Córdova, F. M. Glaser, V. Walz, R. Cunha, R. A. Leal, R. B. Latini, A. Prediger, R. D. S. |
Keywords: | DARPP-32; dyskinesia; exercise; l-DOPA; Parkinson’s disease; 6-OHDA | Issue Date: | 23-Jul-2013 | Publisher: | Elsevier | Citation: | JR., A. S. Aguiar [et al.] - Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice. "Neuroscience". ISSN 0306-4522. Vol. 243 (2013) p. 46-53 | Serial title, monograph or event: | Neuroscience | Volume: | 243 | Abstract: | l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling. | URI: | https://hdl.handle.net/10316/27237 | ISSN: | 0306-4522 | DOI: | 10.1016/j.neuroscience.2013.03.039 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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