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Title: Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice
Authors: Jr., A. S. Aguiar 
Moreira, E. L. G. 
Hoeller, A. A. 
Oliveira, P. A. 
Córdova, F. M. 
Glaser, V. 
Walz, R. 
Cunha, R. A. 
Leal, R. B. 
Latini, A. 
Prediger, R. D. S. 
Keywords: DARPP-32; dyskinesia; exercise; l-DOPA; Parkinson’s disease; 6-OHDA
Issue Date: 23-Jul-2013
Publisher: Elsevier
Citation: JR., A. S. Aguiar [et al.] - Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice. "Neuroscience". ISSN 0306-4522. Vol. 243 (2013) p. 46-53
Abstract: l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling.
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2013.03.039
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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