Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27237
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jr., A. S. Aguiar | - |
dc.contributor.author | Moreira, E. L. G. | - |
dc.contributor.author | Hoeller, A. A. | - |
dc.contributor.author | Oliveira, P. A. | - |
dc.contributor.author | Córdova, F. M. | - |
dc.contributor.author | Glaser, V. | - |
dc.contributor.author | Walz, R. | - |
dc.contributor.author | Cunha, R. A. | - |
dc.contributor.author | Leal, R. B. | - |
dc.contributor.author | Latini, A. | - |
dc.contributor.author | Prediger, R. D. S. | - |
dc.date.accessioned | 2014-10-13T14:12:34Z | - |
dc.date.available | 2014-10-13T14:12:34Z | - |
dc.date.issued | 2013-07-23 | - |
dc.identifier.citation | JR., A. S. Aguiar [et al.] - Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice. "Neuroscience". ISSN 0306-4522. Vol. 243 (2013) p. 46-53 | por |
dc.identifier.issn | 0306-4522 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27237 | - |
dc.description.abstract | l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling. | por |
dc.language.iso | por | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | DARPP-32 | por |
dc.subject | dyskinesia | por |
dc.subject | exercise | por |
dc.subject | l-DOPA | por |
dc.subject | Parkinson’s disease | por |
dc.subject | 6-OHDA | por |
dc.title | Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice | por |
dc.type | article | por |
degois.publication.firstPage | 46 | por |
degois.publication.lastPage | 53 | por |
degois.publication.title | Neuroscience | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0306452213002832 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.neuroscience.2013.03.039 | - |
degois.publication.volume | 243 | por |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | pt | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Exercise attenuates levodopa-induced dyskinesia (2).pdf | 904.46 kB | Adobe PDF | View/Open |
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