Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/25475
Title: Ln[DO3A-N-α-(pyrenebutanamido)propionate] complexes: optimized relaxivity and NIR optical properties†
Authors: Ferreira, M. F. 
Pereira, G. 
Martins, A. F. 
Martins, C. I. O. 
Prata, M. I. M. 
Petoud, S. 
Toth, E. 
Ferreira, P. M. T. 
Martins, J. A. 
Geraldes, C. F. G. C. 
Keywords: MRI CONTRAST AGENTS; NEPHROGENIC SYSTEMIC FIBROSIS; HUMAN SERUM-ALBUMIN; ACID GD-COMPLEX; WATER EXCHANGE; LANTHANIDE(III) COMPLEXES; SILICA NANOPARTICLES; QUANTUM YIELDS; IMAGING AGENTS; O-17 NMR
Issue Date: 2014
Publisher: The Royal Society of Chemistry
Abstract: We have proposed recently that the DO3A-N-α-(amino)propionate chelator and its amide conjugates are leads to targeted, high relaxivity, safe contrast agents for magnetic resonance imaging. In this work we illustrate further the expeditious nature and robustness of the synthetic methodologies developed by preparing the DO3A-N-(α-pyrenebutanamido)propionate chelator. Its Gd3+ chelate retains the optimized water exchange, high stability and inertness of the parent complex. The pyrene moiety imparts concentration- dependent self-assembly properties and aggregation-sensitive fluorescence emission to the Gd3+ complex. The Gd3+ complex displays pyrene-centred fluorescence whilst the Yb3+ and Nd3+ complexes exhibit sensitized lanthanide-centred near-infrared luminescence. The aggregated form of the complex displays high relaxivity (32 mM−1 s−1, 20 MHz, 25 °C) thanks to simultaneous optimization of the rotational correlation time and of the water exchange rate. The relaxivity is however still limited by chelate flexibility. This report demonstrates that the DO3A-N-(α-amino)propionate chelator is a valuable platform for constructing high relaxivity CA using simple design principles and robust chemistries accessible to most chemistry labs.
URI: http://hdl.handle.net/10316/25475
DOI: 10.1039/c3dt52958d
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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