Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/24918
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dc.contributor.authorKjoniksen, A.L.-
dc.contributor.authorCalejo, M. T.-
dc.contributor.authorZhu, K.Z.-
dc.contributor.authorCardoso, A. M .S.-
dc.contributor.authorLima, M.C.P. de-
dc.contributor.authorJurado, A.S.-
dc.contributor.authorNystrom, B.-
dc.contributor.authorSande, S.A.-
dc.date.accessioned2014-01-17T11:19:38Z-
dc.date.available2014-01-17T11:19:38Z-
dc.date.issued2013-11-
dc.identifier.issn0022-3549-
dc.identifier.urihttp://hdl.handle.net/10316/24918-
dc.description.abstractThe release of the opioid antagonist naltrexone from neutral poly(N-isopropylacrylamide) (PNIPAAM)microgels and negatively charged PNIPAAM microgels containing acrylic acid groups (PNIPAAM-co-PAA) has been studied at various microgel and drug concentrations. The release curves were found to be well represented by the Weibull equation. The release rates were observed to be dependent on the microgel concentration. At most conditions, the release from the charged microgels was slower than for the neutral microgels. In addition, the charged microgels exhibited a release lag time, which was dependent on the microgel concentration. No significant lag time could be observed for the neutral microgels. Increasing the naltrexone concentration did not significantly affect the release rates from the neutral microgels, but the release from the charged microgels became faster. The microgels did not exhibit any significant cytotoxic effect on HeLa cells at the tested concentrations.por
dc.description.sponsorshipNorwegian Research Councilpor
dc.language.isoengpor
dc.publisherWILEY-BLACKWELLpor
dc.rightsopenAccesspor
dc.subjectControlled releasepor
dc.subjectDrug delivery systemspor
dc.subjectMacromolecular drug deliverypor
dc.subjectMicroencapsulationpor
dc.subjectMicroparticlespor
dc.subjectPolymeric drug delivery systemspor
dc.titleSustained Release of Naltrexone from Poly(N-Isopropylacrylamide) Microgelspor
dc.typearticlepor
degois.publication.firstPage227por
degois.publication.lastPage234por
degois.publication.titleJournal of Pharmaceutical Sciencespor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/jps.23780/pdfpor
dc.peerreviewedYespor
dc.identifier.doi10.1002/jps.23780-
degois.publication.volume103por
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-1844-5027-
crisitem.author.orcid0000-0001-7095-5337-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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