Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/23523
Title: Multimodal Imaging Probes for the Diagnostics of Alzheimer’s Disease
Authors: Martins, Andre Ferreira 
Orientador: Geraldes, Carlos
Toth, Eva Jakab
Keywords: Alzheimer; MRI
Issue Date: 12-Jun-2013
Citation: MARTINS, André Ferreira - Multimodal imaging probes for the diagnostics of Alzheimer’s Disease. Coimbra : [s.n.], 2013. Tese de doutoramento. Disponível na WWW: http://hdl.handle.net/10316/23523
Abstract: Alzheimer’s disease (AD) is the most frequent form of intellectual deterioration in elderly individuals, characterized by the brain deposition of amyloid plaques and neurofibrillary tangles. Early detection of the β-amyloid (Aβ) deposits in vivo is very difficult. Recently 11C-radiolabeled small-molecules have been developed, capable of entering the brain and specifically targeting amyloid plaques for imaging with PET, such as several Thioflavin T derivatives. In particular, the uncharged analogue 6-OH-BTA-1 (Pittsburgh compound B- PiB) is highly efficient both in crossing the BBB and in selective binding to AD amyloid aggregates. The use of Aβ marker linked to a MRI CA would constitute an attractive noninvasive in vivo imaging approach.
Description: Tese de doutoramento em Bioquímica, na especialidade de Biofísica Molecular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra
URI: http://hdl.handle.net/10316/23523
Rights: embargoedAccess
Appears in Collections:FCTUC Ciências da Vida - Teses de Doutoramento

Files in This Item:
File Description SizeFormat
Multimodal Imaging Probes.pdfVersão provisória31.64 MBUnknownView/Open
Show full item record

Page view(s) 20

544
checked on Sep 15, 2020

Download(s) 50

240
checked on Sep 15, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.