Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/11808
Título: The inflammatory response in mild and in severe psoriasis
Autor: Rocha-Pereira, P. 
Santos-Silva, A. 
Rebelo, I. 
Figueiredo, A. 
Quintanilha, A. 
Teixeira, F. 
Palavras-chave: C-reactive protein; Inflammation; Neutrophil activation; Neutrophilic elastase; Oxidative stress; Psoriasis activity
Data: 6-Mai-2004
Editora: Blackwell Publishing
Citação: British Journal of Dermatology. 150:5 (2004) 917-928
Resumo: Background Psoriasis is a chronic and recurrent inflammatory skin disease. The inflammatory response represents a fundamental ability of the organism to protect itself from infectious agents and from injury. Objectives To evaluate the inflammatory response in mild and in severe psoriasis, to evaluate the endogenous systems counterbalancing the deleterious effects of the inflammation products, and to establish values of prognostic significance. Methods The study was performed in a control group (n . 40) and in 60 patients with psoriasis vulgaris, half presenting with mild psoriasis, and the other half with severe psoriasis. We evaluated total and differential leucocyte count; elastase, lactoferrin and lipid peroxidation as markers of neutrophil activation; total plasma antioxidant capacity (TAS), transferrin, ceruloplasmin, a1-antitrypsin and a2-macroglobulin as markers of the endogenous antioxidant and antiprotease systems; and fibrinogen, erythrocyte sedimentation rate, C-reactive protein (CRP), haptoglobin, C3 and C4 complement proteins as markers of inflammation. Results Our data suggested that psoriasis is an inflammatory condition in which neutrophils seem to play a crucial role by contributing to the development of oxidative and proteolytic stress. The worsening of the disease seemed to be linked to the enhancement of the inflammatory response and of the imbalance between neutrophil activation products and their inhibitors. Conclusions We propose values for elastase, CRP, elastase . a2-macroglobulin, elastase . a1-antitrypsin, thiobarbituric acid . TAS and elastase . neutrophil ratios with prognostic significance for the worsening of psoriasis.
URI: https://hdl.handle.net/10316/11808
ISSN: 0007-0963
DOI: 10.1111/j.1365-2133.2004.05984.x
Direitos: openAccess
Aparece nas coleções:FMUC Medicina - Artigos em Revistas Internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato
The inflammatory response in mild and in severe psoriasis.pdf306.96 kBAdobe PDFVer/Abrir
Mostrar registo em formato completo

Citações SCOPUSTM   

207
Visto em 17/nov/2022

Citações WEB OF SCIENCETM

181
Visto em 2/mai/2023

Visualizações de página

353
Visto em 26/mar/2024

Downloads 50

409
Visto em 26/mar/2024

Google ScholarTM

Verificar

Altmetric

Altmetric


Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.