Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/113935
Título: | The role of early functional neuroimaging in predicting neurodevelopmental outcomes in neonatal encephalopathy | Autor: | Pinto, Carla R. Duarte, João V. Marques, Carla Vicente, Inês N. Paiva, Catarina Éloi, João Pereira, Daniela J. Correia, Bárbara R. Castelo-Branco, Miguel Oliveira, Guiomar |
Palavras-chave: | Perinatal asphyxia; Neonatal encephalopathy; Newborn; Prognosis; Functional neuroimaging; Neurodevelopmental outcome | Data: | Mar-2023 | Editora: | Springer Nature | Projeto: | PTDC/ DTP-PIC/6032/2014/POCI-01–0145-FEDER-016781 | Título da revista, periódico, livro ou evento: | European Journal of Pediatrics | Volume: | 182 | Número: | 3 | Resumo: | Reliably assessing the early neurodevelopmental outcomes in infants with neonatal encephalopathy (NE) is of utmost importance to advise parents and implement early and personalized interventions. We aimed to evaluate the accuracy of neuroimaging modalities, including functional magnetic resonance imaging (fMRI) in predicting neurodevelopmental outcomes in NE. Eighteen newborns with NE due to presumed perinatal asphyxia (PA) were included in the study, 16 of whom underwent therapeutic hypothermia. Structural magnetic resonance imaging (MRI), and fMRI during passive visual, auditory, and sensorimotor stimulation were acquired between the 10th and 14th day of age. Clinical follow-up protocol included visual and auditory evoked potentials and a detailed neurodevelopmental evaluation at 12 and 18 months of age. Infants were divided according to sensory and neurodevelopmental outcome: severe, moderate disability, or normal. Structural MRI findings were the best predictor of severe disability with an AUC close to 1.0. There were no good predictors to discriminate between moderate disability versus normal outcome. Nevertheless, structural MRI measures showed a significant correlation with the scores of neurodevelopmental assessments. During sensorimotor stimulation, the fMRI signal in the right hemisphere had an AUC of 0.9 to predict absence of cerebral palsy (CP). fMRI measures during auditory and visual stimulation did not predict sensorineural hearing loss or cerebral visual impairment. | URI: | https://hdl.handle.net/10316/113935 | ISSN: | 1432-1076 | DOI: | 10.1007/s00431-022-04778-0 | Direitos: | openAccess |
Aparece nas coleções: | I&D ICNAS - Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
The-role-of-early-functional-neuroimaging-in-predicting-neurodevelopmental-outcomes-in-neonatal-encephalopathyEuropean-Journal-of-Pediatrics.pdf | 856.41 kB | Adobe PDF | Ver/Abrir |
Visualizações de página
21
Visto em 8/mai/2024
Downloads
21
Visto em 8/mai/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons