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https://hdl.handle.net/10316/113885
Título: | Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy | Autor: | Shao, Minmin Lopes, Daniela Lopes, Joana Yousefiasl, Satar Macário-Soares, Ana Peixoto, Diana Ferreira-Faria, Inês Veiga, Francisco Conde, João Huang, Yi Chen, Xianfeng Paiva-Santos, Ana Cláudia Makvandi, Pooyan |
Data: | 2023 | Editora: | Elsevier | Projeto: | Theauthorsacknowledge thefinancial support fromthegrants2021.05914.BD (giventoD.P.) andPTDC/BTM-MAT/4738/2020project (giventoA.C.P.-S., J.C., andF.V.) fromFundac¸a˜oparaaCie ˆnciaeTecnologia (FCT). J.C. acknowledges theEuropeanResearchCouncilStartingGrant(ERC-StG-2019-848325) | Título da revista, periódico, livro ou evento: | Matter | Volume: | 6 | Número: | 3 | Resumo: | Bio-mimicking principles have recently been proposed for the surface functionalization of nanoparticles (NPs). Such a strategy is based on camouflaging the NP surface with functional biomembranes to render superior biocompatibility, interfacial features, immune evasion, and active targeting properties to nanomaterials. In this area of research, cell membranes derived from a plethora of highly optimized cells, such as red blood cells, immune cells, platelets, stemcells, cancer cells, and others, have been the pioneers as coatingmaterials. This biomimetic concept has then been applied to subcellular structures, namely extracellular vesicles and intracellular organelles. Exosomes are a nanosized extracellular vesicle subtype secreted by most cells. These phospholipid bilayer nanovesicles are surface enriched with proteins accounting for their dynamic and prominent roles in immune escape, cell-cell communication, and specific cell uptake. Their intrinsic stability, biocompatibility, reduced immunogenicity and toxicity, and specific cell-targeting features denote an optimal biological nanocarrier for biomedical applications. This review highlights the current clinical applications of exosome membrane-coated nanosystems in cancer diagnosis and therapy. These biomimetic nanosystems have emerged as a promising avenue to provide effective, highly specific, and safer cancer-targeted applications. Finally, challenges hindering their clinical application will be mentioned. | URI: | https://hdl.handle.net/10316/113885 | ISSN: | 25902385 | DOI: | 10.1016/j.matt.2023.01.012 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Exosome membrane-coated nanosystems Exploring biomedical applications in cancer diagnosis and therapy.pdf | 11.11 MB | Adobe PDF | Ver/Abrir |
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