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https://hdl.handle.net/10316/113796
Title: | Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release | Authors: | Tundisi, Louise Lacalendola Ataide, Janaína Artem da Fonseca, Jéssica Heline Lopes Silvério, Luiza Aparecida Luna Lancellotti, Marcelo Paiva-Santos, Ana Cláudia d’Ávila, Marcos Akira Kohane, Daniel S. Mazzola, Priscila Gava |
Keywords: | hydrogel; terbinafine; poloxamer 407; nanoparticle; drug release; rheology; polycaprolactone | Issue Date: | 2023 | Publisher: | MDPI | Project: | FAPESP (2017/10728-2, 2018/06475-4, 2018/07707- 6, 2018/05421-8) Capes (Finance code 001) CNPq (301436/2017-7, 308569/2018-0) |
Serial title, monograph or event: | Pharmaceutics | Volume: | 15 | Issue: | 3 | Abstract: | A poloxamer 407 (P407)—Casein hydrogel was chosen to carry polycaprolactone nanoparticles carrying terbinafine (PCL-TBH-NP). In this study, terbinafine hydrochloride (TBH) was encapsulated into polycaprolactone (PCL) nanoparticles, which were further incorporated into a poloxamercasein hydrogel in a different addition order to evaluate the effect of gel formation. Nanoparticles were prepared by the nanoprecipitation technique and characterized by evaluating their physicochemical characteristics and morphology. The nanoparticles had a mean diameter of 196.7 0.7 nm, PDI of 0.07, negative potential (0.713 mV), high encapsulation efficiency (>98%), and did not show cytotoxic effects in primary human keratinocytes. PCL-NP modulated terbinafine was released in artificial sweat. Rheological properties were analyzed by temperature sweep tests at different addition orders of nanoparticles into hydrogel formation. The rheological behavior of nanohybrid hydrogels showed the influence of TBH-PCL nanoparticles addition in the mechanical properties of the hydrogel and a long-term release of the nanoparticles from it. | URI: | https://hdl.handle.net/10316/113796 | ISSN: | 1999-4923 | DOI: | 10.3390/pharmaceutics15030841 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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Terbinafine-Nanohybrid-Proposing-a-Hydrogel-Carrying-Nanoparticles-for-Topical-ReleasePharmaceutics.pdf | 4.14 MB | Adobe PDF | View/Open |
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