Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113796
DC Field | Value | Language |
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dc.contributor.author | Tundisi, Louise Lacalendola | - |
dc.contributor.author | Ataide, Janaína Artem | - |
dc.contributor.author | da Fonseca, Jéssica Heline Lopes | - |
dc.contributor.author | Silvério, Luiza Aparecida Luna | - |
dc.contributor.author | Lancellotti, Marcelo | - |
dc.contributor.author | Paiva-Santos, Ana Cláudia | - |
dc.contributor.author | d’Ávila, Marcos Akira | - |
dc.contributor.author | Kohane, Daniel S. | - |
dc.contributor.author | Mazzola, Priscila Gava | - |
dc.date.accessioned | 2024-03-04T12:48:25Z | - |
dc.date.available | 2024-03-04T12:48:25Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1999-4923 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113796 | - |
dc.description.abstract | A poloxamer 407 (P407)—Casein hydrogel was chosen to carry polycaprolactone nanoparticles carrying terbinafine (PCL-TBH-NP). In this study, terbinafine hydrochloride (TBH) was encapsulated into polycaprolactone (PCL) nanoparticles, which were further incorporated into a poloxamercasein hydrogel in a different addition order to evaluate the effect of gel formation. Nanoparticles were prepared by the nanoprecipitation technique and characterized by evaluating their physicochemical characteristics and morphology. The nanoparticles had a mean diameter of 196.7 0.7 nm, PDI of 0.07, negative potential (0.713 mV), high encapsulation efficiency (>98%), and did not show cytotoxic effects in primary human keratinocytes. PCL-NP modulated terbinafine was released in artificial sweat. Rheological properties were analyzed by temperature sweep tests at different addition orders of nanoparticles into hydrogel formation. The rheological behavior of nanohybrid hydrogels showed the influence of TBH-PCL nanoparticles addition in the mechanical properties of the hydrogel and a long-term release of the nanoparticles from it. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | FAPESP (2017/10728-2, 2018/06475-4, 2018/07707- 6, 2018/05421-8) Capes (Finance code 001) | pt |
dc.relation | CNPq (301436/2017-7, 308569/2018-0) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | hydrogel | pt |
dc.subject | terbinafine | pt |
dc.subject | poloxamer 407 | pt |
dc.subject | nanoparticle | pt |
dc.subject | drug release | pt |
dc.subject | rheology | pt |
dc.subject | polycaprolactone | pt |
dc.title | Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release | pt |
dc.type | article | - |
degois.publication.firstPage | 841 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | Pharmaceutics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/pharmaceutics15030841 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2023-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.orcid | 0000-0003-2710-6000 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Terbinafine-Nanohybrid-Proposing-a-Hydrogel-Carrying-Nanoparticles-for-Topical-ReleasePharmaceutics.pdf | 4.14 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License