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Title: | Umbilical-Cord-Derived Mesenchymal Stromal Cells Modulate 26 Out of 41 T Cell Subsets from Systemic Sclerosis Patients | Authors: | Laranjeira, Paula Dos Santos, Francisco Salvador, Maria João Simões, Irina N. Cardoso, Carla M. P. Silva, Bárbara M. Henriques-Antunes, Helena Corte-Real, Luísa Couceiro, Sofia Monteiro, Filipa Santos, Carolina Santiago, Tânia Silva, José A. P. da Paiva, Artur |
Keywords: | mesenchymal stromal cells (MSCs); mesenchymal stemcells; immunomodulatory potential; systemic sclerosis; T cells; T cell polarization; T cell activation; Treg; Th17; cellular therapy | Issue Date: | 30-Apr-2023 | Publisher: | MDPI | Project: | This research was funded by the MSCellProduction project (POCI-01-0247-FEDER-038313) for Portugal 2020, under the Programa Operacional Competitividade e Internacionalização, grating the amount of EUR 547,571.40, of which EUR 327,435.43 came from the European Regional Development Fund. Funding was also provided by the CellTherapy4COVID19 project (POCI-01-02B7-FEDER- 048816) of Portugal 2020 under the Programa Operacional Competitividade e Internacionalização, grating the amount of EUR 430.523,50, of which EUR 344.418,80 came from the European Regional Development Fund | Serial title, monograph or event: | Biomedicines | Volume: | 11 | Issue: | 5 | Abstract: | Systemic sclerosis (SSc) is an immune-mediated disease wherein T cells are particularly implicated, presenting a poor prognosis and limited therapeutic options. Thus, mesenchymal-stem/stromal-cell (MSC)-based therapies can be of great benefit to SSc patients given their immunomodulatory, anti-fibrotic, and pro-angiogenic potential, which is associated with low toxicity. In this study, peripheral blood mononuclear cells from healthy individuals (HC, n = 6) and SSc patients (n = 9) were co-cultured with MSCs in order to assess how MSCs affected the activation and polarization of 58 different T cell subsets, including Th1, Th17, and Treg. It was found that MSCs downregulated the activation of 26 out of the 41 T cell subsets identified within CD4+, CD8+, CD4+CD8+, CD4-CD8-, and γδ T cells in SSc patients (HC: 29/42) and affected the polarization of 13 out of 58 T cell subsets in SSc patients (HC: 22/64). Interestingly, SSc patients displayed some T cell subsets with an increased activation status and MSCs were able to downregulate all of them. This study provides a wide-ranging perspective of how MSCs affect T cells, including minor subsets. The ability to inhibit the activation and modulate the polarization of several T cell subsets, including those implicated in SSc's pathogenesis, further supports the potential of MSC-based therapies to regulate T cells in a disease whose onset/development may be due to immune system's malfunction. | URI: | https://hdl.handle.net/10316/113268 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines11051329 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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